69453
L-Homocysteine
≥98.0% (NT)
Synonym(s):
(S)-2-Amino-4-mercaptobutyric acid
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About This Item
Linear Formula:
HSCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
135.18
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
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product name
L-Homocysteine, ≥98.0% (NT)
Assay
≥98.0% (NT)
form
powder
optical activity
[α]/D 25.5±1.5°, c = 1 in 1 M HCl
color
white
mp
263-265 °C
application(s)
cell analysis
relevant disease(s)
Alzheimer′s disease
storage temp.
−20°C
SMILES string
N[C@@H](CCS)C(O)=O
InChI
1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1
InChI key
FFFHZYDWPBMWHY-VKHMYHEASA-N
General description
L-homocysteine is used to diagnose homocystinuria.
Application
L-homocysteine has been used as a supplement in cell culture media.
Biochem/physiol Actions
Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Certificates of Analysis (COA)
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K Mehlig et al.
Heart (British Cardiac Society), 99(23), 1761-1765 (2013-09-10)
An elevated level of total plasma homocysteine (tHcy) has been associated with risk of coronary heart disease (CHD). The level of tHcy is affected by lifestyle, in addition to genetic predisposition. The methylene tetrahydrofolate reductase (MTHFR) 677C>T polymorphism (rs1801133) is
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American journal of obstetrics and gynecology, 211(4), 373-373 (2014-03-19)
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Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and
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