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T2528

Sigma-Aldrich

Terbutaline hemisulfate salt

Synonym(s):

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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About This Item

Linear Formula:
C12H19NO3 · 1/2H2SO4
CAS Number:
23031-32-5
Molecular Weight:
274.32
EC Number:
245-386-3
MDL number:
MFCD00079584
UNSPSC Code:
12352200
PubChem Substance ID:
24278729
NACRES:
NA.77

solubility

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

originator

Novartis

SMILES string

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153) , ADRB2(154) , ADRB3(155)

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Application

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

Biochem/physiol Actions

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

Features and Benefits

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Preparation Note

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H361,H370

Hazard Classifications

Repr. 2 - STOT SE 1

Target Organs

Cardio-vascular system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Anthony M J Sanchez et al.
European journal of applied physiology, 113(2), 411-418 (2012-07-07)
This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake [Formula: see
Tito Atienza et al.
Respirology (Carlton, Vic.), 18(2), 354-363 (2012-11-07)
To evaluate the efficacy and tolerability of budesonide/formoterol as maintenance and reliever therapy versus budesonide/formoterol maintenance plus terbutaline in adults with persistent asthma not adequately controlled with inhaled corticosteroid (ICS) therapy alone. In this 12-month, randomized, double-blind, parallel-group, phase III
S Akhtar et al.
Critical care medicine, 27(8), 1551-1556 (1999-09-02)
Intraparenchymal airways are involved in air flow regulation. Relaxation of intraparenchymal airways to volatile anesthetics varied by topographic location. This study was conducted to determine whether other bronchodilators (terbutaline, diltiazem, and aminophylline) relax bronchiolus to a greater degree than bronchus
Zbys Fedorowicz et al.
The Cochrane database of systematic reviews, 5(5), CD008585-CD008585 (2012-05-18)
Dysmenorrhoea is a common gynaecological complaint that can affect as many as 50% of premenopausal women, 10% of whom suffer severely enough to be rendered incapacitated for one to three days during each menstrual cycle. Primary dysmenorrhoea is where women
Jodie M Dodd et al.
The Cochrane database of systematic reviews, 12, CD003927-CD003927 (2012-12-14)
Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation. To assess the effects of oral betamimetic maintenance therapy after threatened preterm labour
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Chromatograms

application for HPLC

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