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SAE0080

Sigma-Aldrich

Lipodisq® Styrene:Maleic Anhydride Copolymer 1:1, Pre-hydrolyzed

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

General description

This product is the pre-hydrolyzed form of the Styrene:Maleic Anhydride Copolymer 1:1. It can be regarded, in effect, as Styrene:Maleic Acid Copolymer 1:1 (SMA Copolymer 1:1).

Application

Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.

Functional pH range: 3.5 - 5.5

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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