P1093
Monoclonal Anti-Paxillin antibody produced in mouse
clone PXC-10, ascites fluid
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PXC-10, monoclonal
mol wt
antigen 68-40 kDa
contains
15 mM sodium azide
species reactivity
bovine, rat, human, chicken, hamster
technique(s)
immunocytochemistry: suitable
microarray: suitable
western blot: 1:500 using a cultured human cell line extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PXN(5829)
rat ... Pxn(360820)
General description
Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.
Specificity
Recognizes an epitope located in the LIM1 domain of the paxillin molecule.
Immunogen
C-terminal part of recombinant chicken paxillin (amino acids 305-559)
Application
Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.
Biochem/physiol Actions
Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Paxillin: a new vinculin-binding protein present in focal adhesions.
Turner CE, et al.
The Journal of cell biology, 111(3), 1059-1068 (1990)
Paxillin: a crossroad in pathological cell migration
Lopez CAM, et al.
Journal of Hematology & Oncology, 10(1), 50-50 (2017)
Nien-Yi Chiang et al.
The Journal of biological chemistry, 286(16), 14215-14225 (2011-02-26)
Loss-of-function mutations in the gene encoding G protein-coupled receptor 56 (GPR56) lead to bilateral frontoparietal polymicrogyria (BFPP), an autosomal recessive disorder affecting brain development. The GPR56 receptor is a member of the adhesion-GPCR family characterized by the chimeric composition of
Gokhan Bahcecioglu et al.
International journal of biological macromolecules, 122, 1152-1162 (2018-09-16)
In this study, porcine fibrochondrocyte-seeded agarose, methacrylated gelatin (GelMA), methacrylated hyaluronic acid (MeHA) and GelMA-MeHA blend hydrogels, and 3D printed PCL scaffolds were tested under dynamic compression for potential meniscal regeneration in vitro. Cell-carrying hydrogels produced higher levels of extracellular
Emmanuella Tsirimonaki et al.
Virus research, 115(2), 158-168 (2005-09-20)
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus (GA). E5
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service