K3125

Kojic acid

≥98.5% (HPLC), powder, tyrosinase inhibitor

• Synonym(s): 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
• Empirical Formula (Hill Notation): C₆H₆O₄
• CAS Number: 501-30-4
• Molecular Weight: 142.11
• Beilstein: 120895
• EC Number: 207-922-4
• MDL number: MFCD00006580
• UNSPSC Code: 12352106
• PubChem Substance ID: 24896226
• NACRES: NA.77

Properties

• product name: Kojic acid,
• Assay: ≥98.5% (HPLC)
• form: powder
• mp: 152-155 °C (lit.)
• SMILES string: OCC1=CC(=O)C(O)=CO1
• InChI: 1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
• InChI key: BEJNERDRQOWKJM-UHFFFAOYSA-N

Description

Application

Kojic acid has been used:

• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
• as a reference inhibitor standard for screening tyrosinase inhibition
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells

Biochem/physiol Actions

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.

Tyrosinase inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves