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Key Documents

G1921

Sigma-Aldrich

Glypican 3 human

recombinant, expressed in NSO cells

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

biological source

human

Quality Level

200

recombinant

expressed in NSO cells

Assay

≥97% (SDS-PAGE)

form

lyophilized powder

UniProt accession no.

P51654

storage temp.

−20°C

Gene Information

human ... GPC3(2719)

General description

Glypican-3, a cell surface protein, is highly expressed in hepatocellular carcinoma (HCC) and few other human cancers including melanoma. It is a heparan sulfate proteoglycan and is present on the cell surface. Under non-reducing conditions in SDS-PAGE, the glycanated glypican 3 appears as a smear with an apparent molecular mass of 60 - 100 kDa†

Biochem/physiol Actions

Sulfate proteoglycan attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor. Regulates cell survival and inhibits cell proliferation during normal development. Potential use as marker for early disease detection.

Physical form

Lyophilized from a 0.2 μm filtered solution in PBS containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Restriction enzyme cleavage of UV-irradiated DNA: a comparison of far-UV and mid-UV wavelengths.
S P Moore et al.
Photochemistry and photobiology, 45(2), 253-263 (1987-02-01)
Yu-Liang Wang et al.
World journal of gastroenterology, 18(19), 2408-2414 (2012-06-02)
To investigate the diagnostic value of glypican-3 (GPC3) and its relationship with hepatocellular carcinoma (HCC) recurrence after liver transplantation. HCC tissue samples (n = 31) obtained from patients who had undergone liver transplantation were analyzed. GPC3 mRNA and protein expression
Shiro Suzuki et al.
Human vaccines & immunotherapeutics, 10(2), 338-343 (2013-11-21)
Carcinoembryonic antigen glypican-3 (GPC3) is expressed by>40% of ovarian clear cell carcinoma (CCC) and is a promising immunotherapeutic target. We previously reported the safety of and immunological and clinical responses to a GPC3-derived peptide vaccine in a phase I clinical

Articles

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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