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G0549

Sigma-Aldrich

Corosolic acid from Lagerstroemia speciosa

≥98% (HPLC)

Synonym(s):

Corosolic acid, (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid, 2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol

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About This Item

Empirical Formula (Hill Notation):
C30H48O4
CAS Number:
Molecular Weight:
472.70
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25

Quality Level

Assay

≥98% (HPLC)

form

powder

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1

InChI

1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1

InChI key

HFGSQOYIOKBQOW-ZSDYHTTISA-N

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General description

Corosolic acid from Lagerstroemia speciosa is a pentacyclic triterpenoid found in a variety of plants, such as apples, basil, bilberries, cranberries, and prunes. It is a natural derivative of ursolic acid.

Application

Corosolic acid from Lagerstroemia speciosa has been used to study the inhibiting activity of ursolic acid and its derivative against colon cancer cells by causing degradation of β-catenins.

Biochem/physiol Actions

Corosolic acid from Lagerstroemia speciose shows a variety of biological activities such as anti-proliferation, apoptosis, and anti-carcinogenic. It exhibits an inhibiting effect on the post-challenge plasma glucose levels in humans. Corosolic acid, due to its ability to improve glucose metabolism, has been touted to be used in the management of Type-2 Diabetes. It improves hypertension, oxidative stress, and inflammation, thereby being a potential candidate to be used against atherosclerosis-related diseases.
Triterpene phytochemical found in medicinal herbal extracts. Possesses antiatherosclerotic, antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral and antineoplastic activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Fukushima et al.
Diabetes research and clinical practice, 73(2), 174-177 (2006-03-22)
Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on
Myung Sun Lee et al.
Phytotherapy research : PTR, 24(1), 49-53 (2009-06-24)
Four ursane-type triterpenoids, corosolic acid (1), ilekudinol B (2), ursolic acid (3) and pomolic acid (4), were isolated from an EtOAc-soluble extract of the leaves of Weigela subsessilis. These bioactive compounds were evaluated for their glucose uptake activity and produced
Wenli Hou et al.
Phytotherapy research : PTR, 23(5), 614-618 (2008-12-25)
The potential antidiabetic activity of ethyl acetate extract of the leaves of Lagerstroemia speciosa (LSL) was investigated by alpha-amylase and alpha-glucosidase inhibition assay. Six pentacyclic triterpenes (oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, corosolic acid and 23-hydroxyursolic acid) were
G Sivakumar et al.
Current medicinal chemistry, 18(1), 79-90 (2010-11-30)
Globally, diabetes and obesity are two of the most common metabolic diseases of the 21(st) century. Increasingly, not only adults but children and adolescents are being affected. New approaches are needed to prevent and treat these disorders and to reduce
Kotaro Yamada et al.
Biological & pharmaceutical bulletin, 31(4), 651-655 (2008-04-02)
Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of

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