F9552

Formoterol fumarate dihydrate

>98% (HPLC), solid, β₂-Adrenoreceptor agonist.

• Synonym(s): (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate, Formoterol hemifumarate salt monohydrate
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂O₄ · 0.5C₄H₄O₄ · H₂O
• CAS Number: 183814-30-4
• Molecular Weight: 420.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278448
• NACRES: NA.77
• MDL number: MFCD11045919
• Assay: >98% (HPLC)
• Form: solid

Properties

• Product Name: Formoterol fumarate dihydrate, >98% (HPLC)
• Quality Segment: 100
• assay: >98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: soluble 20 mg/mL, H₂O: insoluble
• originator: Novartis
• SMILES string: O.O.OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@H](C)NC[C@@H](O)c4ccc(O)c(NC=O)c4)cc3
• InChI: 1S/2C19H24N2O4.C4H4O4.2H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;;2-1+;;/t2*13-,19+;;;/m00.../s1
• InChI key: RATSWNOMCHFQGJ-TUYNVFRMSA-N
• Gene Information: human ... ADRB2(154)

Description

Application

Formoterol fumarate dihydrate has been used:

• as β₂-adrenergic agonist, to determine whether β₂-adrenergic receptor signaling was sufficient to induce up-regulation of select gene transcripts
• as a β₂-adrenergic receptor agonist and a long term bronchodilator
• as β₂-adrenergic receptor (β₂AR) agonist to recover renal function in ischemia-reperfusion injury (IRI) in mice

Biochem/physiol Actions

β₂-Adrenoreceptor agonist.

Formoterol fumarate dihydrate can be used along with budesonide to treat asthma.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Codes: H332,H361d,H370,H373,H412
• Precautionary Statements: P202 - P260 - P264 - P273 - P304 + P340 + P312 - P308 + P311
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)