Skip to Content
Merck
All Photos(4)

Documents

C8895

Sigma-Aldrich

Clofazimine

≥98% (TLC), powder, antileprosy drug

Synonym(s):

N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Empirical Formula (Hill Notation):
C27H22Cl2N4
CAS Number:
2030-63-9
Molecular Weight:
473.40
EC Number:
217-980-2
MDL number:
MFCD00056793
UNSPSC Code:
12352200
PubChem Substance ID:
24893114
NACRES:
NA.77

product name

Clofazimine,

form

powder

antibiotic activity spectrum

mycobacteria

Mode of action

protein synthesis | interferes

originator

Novartis

SMILES string

CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5

InChI

1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+

InChI key

WDQPAMHFFCXSNU-BGABXYSRSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:
  • for antimicrobial preparation
  • to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
  • to model drug-induced hepatic granulomatous inflammation
  • to study the in vivo cargo storage capacity of macrophages

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages
Keswani RK, et al.
Cytometry. Part A : the Journal of the International Society For Analytical Cytology, 87(9), 855-867 (2015)
In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants
Ismail N, et al.
Journal of Microbiological Methods, 153(8), 1-9 (2018)
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 3-3 (2019)
Jakko van Ingen et al.
Antimicrobial agents and chemotherapy, 56(12), 6324-6327 (2012-10-03)
Disease caused by nontuberculous mycobacteria (NTM) is increasing in frequency. The outcome of treatment for NTM lung disease is poor, particularly lung disease caused by Mycobacterium simiae and M. abscessus. Exploring synergy between active available drugs is a sensible way
An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 12-12 (2019)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service