SMB01394

p-Cresol glucuronide

≥95% (HPLC)

• Synonym(s): p-Tolyl β-D-glucuronide, pCG
• Empirical Formula (Hill Notation): C₁₃H₁₆O₇
• CAS Number: 17680-99-8
• Molecular Weight: 284.26
• MDL number: MFCD08277028
• UNSPSC Code: 12352201
• Assay: ≥95% (HPLC)
• form: powder or crystals

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: powder or crystals
• technique(s): mass spectrometry (MS): suitable
• color: white to off-white
• application(s): metabolomics
• storage temp.: −20°C
• SMILES string: O([C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O)C2=CC=C(C)C=C2
• InChI: 1S/C13H16O7/c1-6-2-4-7(5-3-6)19-13-10(16)8(14)9(15)11(20-13)12(17)18/h2-5,8-11,13-16H,1H3,(H,17,18)/t8-,9-,10+,11-,13+/m0/s1
• InChI key: JPAUCQAJHLSMQW-XPORZQOISA-N

Description

General description

p-Cresol glucuronide (pCG) is a metabolite of p-cresol, which is produced by the gut microbiota during the metabolism of dietary tyrosine and phenylalanine. p-cresol glucuronide is primarily associated with its role as a biomarker for assessing microbial metabolism and gut health. It is often used in research studies to evaluate the activity of the gut microbiota and its potential impact on health and disease. Additionally, p-cresol glucuronide levels have been studied in relation to conditions such as chronic kidney disease and cardiovascular health.

Biochem/physiol Actions

p-Cresol glucuronide is generated through a process called glucuronidation, which is a phase II metabolism reaction in the liver. In this process, p-cresol, a metabolite produced by the gut microbiota during the breakdown of dietary tyrosine and phenylalanine, undergoes conjugation with glucuronic acid. This conjugation is catalyzed by the enzyme UDP-glucuronosyltransferase (UGT) to form p-cresol glucuronide. The resulting glucuronide metabolite is then excreted in the urine. This process plays a crucial role in the elimination of p-cresol from the body.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable