The solubility of this standard is not tested internally. A literature search suggests that the material is minimally soluble in organic solvents (DMSO, up to 4-5 mg/mL, and sparingly in ethanol and methanol) and soluble in water up to 50 or 100 mg/mL, but hydroxide may need to be added to aid dissolution.
PHR1847
Ceftazidime
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Ceftazidime pentahydrate
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About This Item
Empirical Formula (Hill Notation):
C22H22N6O7S2 · 5H2O
CAS Number:
Molecular Weight:
636.65
UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. C0690500
traceable to USP 1098130
API family
ceftazidime
form
solid
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
storage temp.
-10 to -25°C
SMILES string
[s]1c(nc(c1)\C(=N\OC(C)(C)C(=O)[O-])\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C[n+]4ccccc4)N.O.O.O.O.O
InChI
1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1
InChI key
NMVPEQXCMGEDNH-TZVUEUGBSA-N
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC1680 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
related product
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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I'd like to know how I can solubilize this product (Ceftazidime PHR1847) and what is the solubility limit. Thanks in advance.
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