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L0800000

Lynestrenol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(17α)-19-Norpregn-4-en-20-yn-17-ol

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About This Item

Empirical Formula (Hill Notation):
C20H28O
CAS Number:
52-76-6
Molecular Weight:
284.44
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

lynestrenol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,6,15-18,21H,4-5,7-13H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1

InChI key

YNVGQYHLRCDXFQ-XGXHKTLJSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lynestrenol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Yasir Hasan Siddique et al.
Indian journal of experimental biology, 43(3), 291-293 (2005-04-09)
Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE
Ozlem Ozdegirmenci et al.
Gynecologic and obstetric investigation, 72(1), 10-14 (2011-01-27)
To evaluate the treatment of endometrial hyperplasia (EH) with different progestins. Eighty-two women with simple EH without atypia were included. Patients were offered oral progestagens and were randomized to one of three options for 3 months: medroxyprogesterone acetate (MPA, 10
Eva-Katrin Bentz et al.
Fertility and sterility, 94(7), 2688-2696 (2010-06-12)
To evaluate gene expression signatures of breast tissue in female-to-male (FtM) transsexuals under cross-sex hormone therapy (HT). Prospective cohort study. Academic research institution. Five hormone-naïve FtM transsexuals before and after HT. Breast tissue biopsy before and after 2 years of
Irving Sivin et al.
Contraception, 71(2), 122-129 (2005-02-15)
In a multicenter 1-year trial of contraceptive vaginal rings (rings) involving 150 women, three dose combinations of the progestin Nestorone (NES) and ethinylestradiol (EE) were compared with respect to effectiveness, safety and acceptability. Mean in vitro drug release rates for
Tuomas Korhonen et al.
The Journal of steroid biochemistry and molecular biology, 110(1-2), 56-66 (2008-03-22)
This study examined the cytochrome P450 (CYP) enzyme selectivity of in vitro bioactivation of lynestrenol to norethindrone and the further metabolism of norethindrone. Screening with well-established chemical inhibitors showed that the formation of norethindrone was potently inhibited by CYP3A4 inhibitor
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