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F0005000

Famotidine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Famotidine, N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

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About This Item

Empirical Formula (Hill Notation):
C8H15N7O2S3
CAS Number:
Molecular Weight:
337.45
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP Reference Standard

API family

famotidine

form

solid

packaging

pkg of 110 mg

manufacturer/tradename

EDQM

storage condition

protect from light

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

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General description

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Famotidine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 29(1-2), 2609-2610 (2017)
Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones
Campbell AN and Sherma J
Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)
Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry
Kelani KM, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)
C W Howden et al.
Clinical therapeutics, 18(1), 36-54 (1996-01-01)
Famotidine is a specific, long-acting histamine2-receptor antagonist. It is indicated for the treatment of duodenal ulcer, gastric ulcer, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. Since its introduction for the treatment of acid-related disorders in 1985, an estimated 18.8 million patients
Occupational allergic contact dermatitis from intermediate products in famotidine synthesis.
D Guimaraens et al.
Contact dermatitis, 31(4), 259-260 (1994-10-01)

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