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890870C

Avanti

16:0 TAP

Avanti Research™ - A Croda Brand 890870C

Synonym(s):

1,2-dipalmitoyl-3-trimethylammonium-propane (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C38H76NO4Cl
CAS Number:
139984-36-4
Molecular Weight:
646.47
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2.5 mL (890870C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890870C

concentration

10 mg/mL (890870C-25mg)

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Cl-]

General description

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) is a cationic lipid and a diol based transfection reagent.

Application

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) is suitable to prepare lipid monolayer/liposome:
  • to mimic the presence of the cationic charge localized in the membrane for understanding the electrostatic effects in the biological membranes and to study its interaction with zearalenone and selenate ions
  • to study its effect on the L-pro catalyzed reaction
  • to serve as a positive control, to determine the effectiveness of anionic phospholipids for pro-inflammatory responses

Biochem/physiol Actions

1,2-dipalmitoyl-3-trimethylammonium-propane (16:0 TAP) liposomes are known to promote elevated pro-inflammatory responses.

Packaging

5 mL Clear Glass Sealed Ampule (890870C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Naomi Benne et al.
Journal of controlled release : official journal of the Controlled Release Society, 291, 135-146 (2018-10-27)
Atherosclerosis is the predominant underlying pathology of many types of cardiovascular disease and is one of the leading causes of death worldwide. It is characterized by the retention of oxidized low-density lipoprotein (ox-LDL) in lipid-rich macrophages (foam cells) in the
Detection of L-Proline-Catalyzed Michael Addition Reaction in Model Biomembrane
Hirose M, et al.
Journal of Chemistry, 2019 (2019)
Barbara Gzyl-Malcher et al.
The Journal of membrane biology, 250(3), 273-284 (2017-04-30)
The impact of zearalenone and selenate ions on the monolayers of 1,2-dipalmitoyl-phosphatidylcholine (DPPC), 1,2-dipalmitoyl-3-trimethylammonium-propane (DPTAP), and the lipid mixtures (phospholipids and galactolipids) extracted from wheat plasmalemma has been studied using Langmuir trough technique and Brewster angle microscopy (BAM). The zearalenone
Bao Zhu et al.
Chemosphere, 247, 125876-125876 (2020-01-25)
Aluminium oxide nanoparticles (Al2O3 NPs) potentially cause health hazards after their release into the environment. The crystalline phase of Al2O3 NPs determines their surface structure and the number of functional groups. The adsorption of natural organic matter (NOM) or biomolecules
Ji Wang et al.
Science (New York, N.Y.), 367(6480) (2020-02-23)
Current influenza vaccines only confer protection against homologous viruses. We synthesized pulmonary surfactant (PS)-biomimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), an agonist of the interferon gene inducer STING (stimulator of interferon genes). The adjuvant (PS-GAMP) vigorously augmented influenza vaccine-induced
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