810219P
Avanti
C12-NBD Sphingomyelin
Avanti Research™ - A Croda Brand 810219P, powder
Synonym(s):
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sphingosine-1-phosphocholine
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About This Item
Empirical Formula (Hill Notation):
C41H73N6O9P
CAS Number:
Molecular Weight:
825.03
UNSPSC Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810219P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810219P
shipped in
dry ice
storage temp.
−20°C
General description
C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin. Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.
Application
C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.
Biochem/physiol Actions
Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.
Packaging
5 mL Amber Glass Screw Cap Vial (810219P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Fluorescent and Luminescent Probes for Biological Activity (1999)
Sawaki Tada et al.
FEMS microbiology letters, 298(2), 157-165 (2009-08-05)
Ceramide is an important molecule not only structurally but also regulationally as a modulator of various cellular events. Ceramidase (CDase) are classified into three different types (acid, alkaline, and neutral CDases). Neutral CDase could play an important role in the
Hyun-Seok Lee et al.
International journal of molecular sciences, 21(3) (2020-02-08)
Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Tada S, et al.
FEMS Microbiology Letters, 298(2), 157-165 (2009)
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can
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