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61250

Sigma-Aldrich

DL-Kynurenine

≥95.0% (NT), for peptide synthesis

Synonym(s):

2-Amino-3-(2-aminobenzoyl)propionic acid, 2-Amino-4-(2-aminophenyl)-4-oxobutyric acid

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O3
CAS Number:
343-65-7
Molecular Weight:
208.21
Beilstein:
2697333
EC Number:
206-445-9
MDL number:
MFCD00025194
UNSPSC Code:
12352209
PubChem Substance ID:
57651839
NACRES:
NA.22

product name

DL-Kynurenine, ≥95.0% (NT)

Assay

≥95.0% (NT)

form

powder

mp

~235 °C (dec.)

application(s)

peptide synthesis

SMILES string

NC(CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)

InChI key

YGPSJZOEDVAXAB-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rahul Shinde et al.
Nature immunology, 19(6), 571-582 (2018-05-16)
The transcription factor AhR modulates immunity at multiple levels. Here we report that phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of the cytokine IL-10. Activation of AhR was dependent on interactions between apoptotic-cell DNA
Adam K Walker et al.
Molecular psychiatry, 24(10), 1523-1532 (2018-07-11)
Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine. Circulating kynurenine is transported into the brain by the large amino transporter LAT1 at the level of the blood-brain barrier. We hypothesized that administration of leucine that has a high
Alban Bessede et al.
Nature, 511(7508), 184-190 (2014-06-17)
Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide
Adam Kosti et al.
Genome biology, 21(1), 195-195 (2020-08-09)
RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification and characterization of oncogenic RBPs and their regulatory
Dag Holmberg et al.
Malaria journal, 16(1), 303-303 (2017-07-30)
One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g. the NMDA-receptor antagonist kynurenic acid (KYNA), has been implicated in long-term cognitive dysfunction in
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