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223867

Sigma-Aldrich

Tolylene-2,6-diisocyanate

97%

Synonym(s):

2-Methyl-m-phenylene diisocyanate

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About This Item

Linear Formula:
CH3C6H3(NCO)2
CAS Number:
91-08-7
Molecular Weight:
174.16
Beilstein:
2211546
EC Number:
202-039-0
MDL number:
MFCD00002010
UNSPSC Code:
12162002
PubChem Substance ID:
24853409
NACRES:
NA.23
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Assay

97%

form

liquid

autoignition temp.

>1148 °F

refractive index

n20/D 1.571 (lit.)

bp

129-133 °C/18 mmHg (lit.)

density

1.225 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Cc1c(cccc1N=C=O)N=C=O

InChI

1S/C9H6N2O2/c1-7-8(10-5-12)3-2-4-9(7)11-6-13/h2-4H,1H3

InChI key

RUELTTOHQODFPA-UHFFFAOYSA-N

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Related Categories

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN2330
SHBK3135
SHBH2200V
SHBG5906V
SHBG3497V

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P Carbonnelle et al.
The Analyst, 121(5), 663-669 (1996-05-01)
In recent years, epidemiological evidence that exposure to toluene diisocyanate (TDI) is associated with adverse health effects has led to the development of useful analytical methods for the biological monitoring of TDI. In this paper, an HPLC method is presented
G Sesana et al.
American Industrial Hygiene Association journal, 52(5), 183-186 (1991-05-01)
A new sampling system is presented that uses solid sorbent media contained in a tube for the determination of airborne isocyanates (2.4-2.6 toluene diisocyanate, hexamethylene diisocyanate, and 4.4' diaminodiphenylmethane diisocyanate). The method is compared with the National Institute for Occupational
B W Day et al.
Chemical research in toxicology, 9(3), 568-573 (1996-04-01)
Guinea pig hemoglobin (Hb) adducts of 2,4- and 2,6-toluene diisocyanate (2,4- and 2,6-TDI) were individually prepared, each at a Hb tetramer to diisocyanate ratio of 1:1, and compared with adducts of Hb from animals exposed to 1 ppm 2,4-TDI vapor.
B W Day et al.
Chemical research in toxicology, 10(4), 424-431 (1997-04-01)
During our ongoing studies of the reactions of toluene diisocyanate (2,4- and 2,6-diisocyanatotoluene, TDI) in vivo, it became apparent that reactive form(s) of these diisocyanates reach(es) the circulatory system after passage through the respiratory system. Based on recent work by
J Huang et al.
Archives of toxicology, 67(6), 373-378 (1993-01-01)
Groups of guinea pigs were exposed via inhalation to toluene diisocyanate (TDI) ranging from 0.02 to 1.0 ppm for 3 h/day on 5 consecutive days. Three weeks later, guinea pigs were challenged with TDI-GSA conjugates. Evaluations were based on TDI
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