SML0228
Rc-Ome
≥98% (HPLC)
Synonym(s):
(2E)-3-(2-hydroxy-5-methoxyphenyl)-1-(4-methoxyphenyl)-2-Propen-1-one, trans-6,4′-dimethoxyretrochalcone
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About This Item
Empirical Formula (Hill Notation):
C17H16O4
CAS Number:
Molecular Weight:
284.31
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
, light to dark yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Application
Rc-Ome may be used in GABAA-mediated cell signaling studies.
Biochem/physiol Actions
Rc-OMe is a GABAA PAM that distinguishes α1β2γ2s from α1β2 receptors. The compound has very weak potentiating effects on α1β2, but potentiates GABA-elicited currents of α(123)β2γ2s receptors, all with low μM EC50s. Rc-OMe acts at a binding site that is distinct from BDZ, pentobarbital and loreclezole modulatory sites.
Features and Benefits
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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