SAB4501665
Anti-Keratin 18 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CK 18, CK18, CYK18, Cytokeratin endo B, K18
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All Photos(3)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
General description
Anti-Keratin 18 antibody detects endogenous levels of total Keratin 18 protein.
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Keratin 18.
Immunogen Range: 381-430
Immunogen Range: 381-430
Biochem/physiol Actions
Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Diptendu Chatterjee et al.
European heart journal, 41(30), 2878-2890 (2020-06-14)
Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 Brugada ECG pattern is often transient, and a genetic cause is only identified in <25% of patients. We sought to identify an
Lucy Pilcher et al.
Stem cells international, 2024, 8601360-8601360 (2024-01-19)
The epicardium is a layer of mesothelial cells that covers the surface of the heart. During development, epicardial cells undergo epithelial-to-mesenchymal transition (EMT) to form multipotent precursors that migrate into the heart and contribute to the coronary vasculature by differentiating
Kasey Y C Lau et al.
Cell stem cell, 29(10), 1445-1458 (2022-09-10)
Several in vitro models have been developed to recapitulate mouse embryogenesis solely from embryonic stem cells (ESCs). Despite mimicking many aspects of early development, they fail to capture the interactions between embryonic and extraembryonic tissues. To overcome this difficulty, we have
Carlos A Pinzón-Arteaga et al.
Cell stem cell, 30(5), 611-616 (2023-05-06)
Understanding the mechanisms of blastocyst formation and implantation is critical for improving farm animal reproduction but is hampered by a limited supply of embryos. Here, we developed an efficient method to generate bovine blastocyst-like structures (termed blastoids) via assembling bovine
Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc developmen
Rodrigues-Pinto R, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(8), 1327-1340 (2016)
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