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Key Documents

L1045

Sigma-Aldrich

LY-354740 hydrate

≥98% (HPLC)

Synonym(s):

(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad, LY-354740

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About This Item

Empirical Formula (Hill Notation):
C8H11NO4 · xH2O
Molecular Weight:
185.18 (anhydrous basis)
UNSPSC Code:
12352209
eCl@ss:
32160406
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

solid

solubility

deionized water: 8 mg/mL

originator

Eli Lilly

storage temp.

room temp

Application

LY-354740 hydrate has been used as a metabotropic glutamate receptor group II/III agonist to study its behavioral effectsof electric shock on Gammarus fossarum.

Biochem/physiol Actions

LY-354740 is a highly selective and potent agonist of group II mGlu (metabotropic glutamate) receptors. It displays antianxiety and antiaddictive activity in vivo. It?s orally and systemically active. It is anxiolytic and inhibits symptoms of morphine withdrawal in morphine-dependent mice.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marie-Jeanne Perrot-Minnot et al.
Royal Society open science, 4(12), 171558-171558 (2018-01-09)
Anxiety is an emotional state generally expressed as sustained apprehension of the environment and elevated vigilance. It has been widely reported in vertebrates and, more recently, in a few invertebrate species. However, its fitness value remains elusive. We investigated anxiety-like
Anxiety-like behaviour increases safety from fish predation in an amphipod crustacea
Perrot M M, et al.
Royal Society open science, 4(12), 171558-171558 (2017)

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