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FCMAB110P

Sigma-Aldrich

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

clone 10H11.E12, from mouse, PE

Synonym(s):

A-T, mutated

AT mutated

TEL1, telomere maintenance 1, homolog

ataxia telangiectasia mutated

ataxia telangiectasia mutated (includes complementation groups A, C and D)

ataxia telangiectasia mutated protein

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

mouse

Quality Level

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

10H11.E12, monoclonal

species reactivity

rat, mouse, human

technique(s)

flow cytometry: suitable

isotype

IgG1κ

NCBI accession no.

General description

N-terminal c-Myc, GST-tagged, recombinant human Cardiac Troponin I full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.

Specificity

Antibody recognizes ATM phosphorylated at Ser1981.
Predicted to cross-react with rat based on sequence homology

Immunogen

Epitope: Phosphorylated at and around Ser1981
KLH-conjugated, synthetic peptide corresponding to human ATM phosphorylated at Ser1981.

Application

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate detects level of phospho-ATM (Ser1981) & has been published & validated for use in FC.

Quality

Evaluated by Flow Cytometry with HeLa cells.

Target description

~370 kDa Calculated

Physical form

Purified mouse monoclonal IgG1κ conjugated to phycoerythrin in PBS with less than 0.09% sodium azide and 15 mg/mL BSA.

Analysis Note

Control
Irradiated HeLa cells

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Yiting Lim et al.
    International journal of radiation oncology, biology, physics, 84(3), 800-806 (2012-03-27)
    We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses
    Sabrina Fritah et al.
    Cancers, 12(9) (2020-09-16)
    Resistance to chemotherapy by temozolomide (TMZ) is a major cause of glioblastoma (GBM) recurrence. So far, attempts to characterize factors that contribute to TMZ sensitivity have largely focused on protein-coding genes, and failed to provide effective therapeutic targets. Long noncoding
    S Masneri et al.
    Stem cell research, 41, 101596-101596 (2019-11-02)
    Using a Sendai Virus based vector delivering Yamanaka Factors, we generated induced Pluripotent Stem Cells (iPSCs) from peripheral blood mononuclear cells of a patient affected by Ataxia Telangiectasia (AT), caused by a novel homozygous deletion in ATM, spanning exons 5-7.

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