Skip to Content
Merck
All Photos(1)

Documents

404322

Sigma-Aldrich

Dichloro(1,2-diaminocyclohexane)platinum(II)

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
[C6H10(NH2)2]PtCl2
CAS Number:
52691-24-4
Molecular Weight:
380.17
MDL number:
MFCD00058826
UNSPSC Code:
12161600
PubChem Substance ID:
24865237
NACRES:
NA.22

reaction suitability

core: platinum
reagent type: catalyst

mp

280 °C (dec.) (lit.)

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kensuke Osada et al.
Journal of the American Chemical Society, 134(32), 13172-13175 (2012-07-28)
Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular
L M Ruiz-Perez et al.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 38(1), 45-48 (1987-03-01)
The trypanocidal activity of three new compounds derived of the antineoplastic drug cis-diamminodichloroplatinum(II) (DDP) has been studied over epimastigote forms of Trypanosoma cruzi. The electron microscopy indicated that, in the treated animals, the nuclear chromatin is distributed in the nucleus
C B Oswald et al.
Research communications in chemical pathology and pharmacology, 64(1), 41-58 (1989-04-01)
The disposition of 3H-cis-1,2-diaminocyclohexanedichloroplatinum (II) and 3H-cis-1,2-diaminocyclohexanemalonatoplatinum (II) was investigated in P388 tumor-bearing BDF1 mice. Fifteen minutes after IP administration of the drugs, the serum contained 12% of the 3H-chloride derivative and 20% of the malonate derivative. Both drugs distributed
A F Nichols et al.
Chemico-biological interactions, 81(3), 223-231 (1992-02-01)
Several studies have implicated enhanced DNA repair in acquired platinum resistance. To better understand the mechanism of increased repair we have employed an in vitro assay using cell-free extracts from platinum sensitive and resistant murine and human cell lines. Since
Isabelle Ourliac-Garnier et al.
Biochemistry, 44(31), 10620-10634 (2005-08-03)
The folding of AG(3)(T(2)AG(3))(3) was investigated in the presence of Na(+) or K(+) ions, by using the dinuclear platinum complexes [{trans-PtCl(NH(3))(2)}(2)H(2)N(CH(2))(n)NH(2)]Cl(2) (n = 2 or 6). AG(3)(T(2)AG(3))(3) has been previously found to adopt two different quadruplex structures: the antiparallel one
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service