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Key Documents

SRP4134

Sigma-Aldrich

IL-3 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

HCGF, IL-3, Interleukin-3, MCGF (Mast cell growth factor), MGC79398, Multi-CSF, P-cell stimulation factor

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

Pricing and availability is not currently available.

biological source

human

recombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

mol wt

~15.0 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

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This Item
SRP3090SRP3275SRP3091
assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

biological source

human

biological source

human

biological source

human

biological source

human

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

Gene Information

human ... IL3(3562)

Gene Information

human ... IL3(3562)

Gene Information

human ... IL33(90865)

Gene Information

human ... IL31(386653)

impurities

endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

impurities

<0.1 EU/μg endotoxin, tested

General description

IL-3 is a species-specific colony-stimulating factor that stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Recombinant human IL-3 is a 15.0 kDa protein containing 133 amino acid residues.

Biochem/physiol Actions

Interleukin-3 (IL-3) is a hematopoietic growth factor. The gene encoding it is localized on human chromosome 5.[1] It has a role in cell proliferation and activates different signaling cascades. It is crucial for the differentiation of hematopoietic-derived endothelial progenitor cells (EPCs). The differentiation of erythroid cells, mast cells and granulocytes is stimulated by IL-3. The protein has been linked to schizophrenia.[2][3][4][5]

Physical form

Lyophilized without additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers.
Baxter EW
Journal of Immunology (2012)
Association of interleukin 3 (IL-3) polymorphisms with schizophrenia in Han Chinese population.
Liu Z
Neuroscience Letters (2015)
The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.
Luo XJ
PLoS ONE (2012)
IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.
Meyer CG
Human Molecular Genetics (2011)
IL-3 is a novel target to interfere with tumor vasculature.
Dentelli P
Oncogene (2011)

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