Skip to Content
Merck

SML1871

Sigma-Aldrich

KIN1400

≥98% (HPLC)

Synonym(s):

7-[(2-Benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C24H17F2N3O2S
CAS Number:
Molecular Weight:
449.47
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 30 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C(N=CC=C1)=C1C=C2)=C2C(C3=CC=C(OC(F)F)C=C3)NC4=NC5=CC=CC=C5S4

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
8149718226581512
transition temp

Tg 63 °C

transition temp

-

transition temp

Tg (DSC) 105 °C (midpoint)

transition temp

-

form

powder

form

-

form

solid

form

-

density

1.11 g/mL at 25 °C

density

1.200 g/cm3

density

1.200 g/cm3

density

1.200 g/cm3

mol wt

average Mw ~515,000 by GPC

mol wt

Mn ~10400, Mp ~10900, Mw ~10900

mol wt

-

mol wt

Mn ~7910, Mp ~8350, Mw ~8290

inherent viscosity

0.80 dL/g(lit.)

inherent viscosity

-

inherent viscosity

-

inherent viscosity

-

Biochem/physiol Actions

KIN1400 is innate immune agonists of IRF3 activation that induces IRF3 and MAVS dependent innate immune antiviral genes and IFNβ expression. KIN1400 is a broad spectrum antiviral compound that suppresses replication of hepatitis C virus, West Nile virus, dengue virus and other Flaviviridae, as well as Filoviridae (EV), Orthomyxoviridae (influenza A virus), Arenaviridae (LV) and Paramyxoviridae (RCV, NV).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

R R Green et al.
Genomics data, 7, 290-292 (2016-03-17)
The recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRR) during viral infection initiates the induction of antiviral signaling pathways, including activation of the Interferon Regulator Factor 3 (IRF3). We identified small molecule compounds that activate IRF3
Sowmya Pattabhi et al.
Journal of virology, 90(5), 2372-2387 (2015-12-18)
The cellular response to virus infection is initiated when pathogen recognition receptors (PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results in induction of downstream signaling pathways that activate the transcription factor interferon regulatory factor 3 (IRF3). IRF3 plays

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service