SML1251

Gomisin A

• Synonym(s): (+)-Gomisin A, (6S,7S,13aR)- 5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol, Besigomsin, Schisandrol B, Schisantherinol B, Schizandrol B, TJN 101, Wuweizi alcohol B, Wuweizichun B
• Empirical Formula (Hill Notation): C₂₃H₂₈O₇
• CAS Number: 58546-54-6
• Molecular Weight: 416.46
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825744
• NACRES: NA.77

Properties

• biological source: Schisandra chinensis
• Quality Level: 100
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1
• InChI: 1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1
• InChI key: ZWRRJEICIPUPHZ-MYODQAERSA-N

Description

Biochem/physiol Actions

Gomisin A guards against hepatic and renal injury stimulated by CCl(4) (carbon tetrachloride) exposure by differential modulation of the mitogen-activated protein kinases (MAPK) signal transduction pathway. It also blocks inflammatory responses, promoted by lipopolysaccharide in N9 microglia by blocking the NF-κB (nuclear factor kappa light chain enhancer of activated B cells)/MAPKs pathway.

Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese that exhibit a wide variety of interesting biological activities, including hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory. Gomisin A suppressed the expressions of iNOS and COX-2 in LPS-stimulated N9 microglia through suppression of NF-κB/MAPKs pathway.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable