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SML0468

Sigma-Aldrich

Dorzolamide

≥98% (HPLC)

Synonym(s):

(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O4S3
CAS Number:
120279-96-1
Molecular Weight:
324.44
MDL number:
MFCD00865636
UNSPSC Code:
12352200
PubChem Substance ID:
329824746
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -25 to -35°, c = 1 in methanol

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1

InChI key

IAVUPMFITXYVAF-XPUUQOCRSA-N

Gene Information

human ... CA2(760)

Biochem/physiol Actions

Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Daniel Laroche et al.
Journal of glaucoma, 27(10), e158-e161 (2018-07-26)
We describe a novel technique comprising the use of trypan blue to confirm aqueous outflow to collector channels and aqueous veins after goniotomy with the Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA). Intraocular dyes have been safely used
John S Sapienza et al.
Veterinary ophthalmology, 22(4), 520-528 (2018-10-26)
The purpose of this study was to report the preliminary results of a novel micropulse transscleral diode laser cyclophotocoagulation (MP-TSCP) as primary therapy for glaucomatous dogs. Client owned dogs undergoing MP-TSCP therapy at a veterinary referral center. Retrospective study of
Un Chul Park et al.
Retina (Philadelphia, Pa.), 40(7), 1359-1366 (2019-06-06)
To evaluate the efficacy and safety of intravitreal dexamethasone (DEX) implant in retinitis pigmentosa patients with cystoid macular edema (CME). In this randomized, noncontrolled, paired-eye, single crossover clinical trial, one eye of retinitis pigmentosa patients with bilateral CME with central
Rodolfo Mastropasqua et al.
Ophthalmic surgery, lasers & imaging retina, 49(9), e20-e31 (2018-09-18)
The aim of the study was to determine optical coherence tomography angiography (OCTA) findings and to identify mutations in the RS1 gene in a three-generation family with X-linked juvenile retinoschisis (XLRS). Clinical and genetic assessments were performed in 12 family
Luciano Quaranta et al.
Journal of glaucoma, 26(11), 987-994 (2017-09-29)
To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible.
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