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SAB3501154

Sigma-Aldrich

Monoclonal Anti-DC-SIGN [5D7] antibody produced in mouse

affinity purified immunoglobulin (IgG)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Pricing and availability is not currently available.

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

affinity purified immunoglobulin (IgG)

antibody product type

primary antibodies

clone

monoclonal

form

liquid

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

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This Item
SAB3501155SAB3501187SAB1410626
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human, mouse

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity purified immunoglobulin (IgG)

antibody form

affinity purified immunoglobulin (IgG)

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

clone

monoclonal

clone

monoclonal

clone

polyclonal

clone

polyclonal

General description

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Immunogen

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Application

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 μg/mL and in immunohistochemistry at 5 - 10 μg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Physical form

Supplied in PBS containing 0.02% sodium azide.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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