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PZ0393

Sigma-Aldrich

Oxamniquine

≥98% (HPLC)

Synonym(s):

(2-((isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl)methanol, 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol

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About This Item

Empirical Formula (Hill Notation):
C14H21N3O3
CAS Number:
21738-42-1
Molecular Weight:
279.33
MDL number:
MFCD00866725
UNSPSC Code:
41121800
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

faint yellow to dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

InChI

1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3

InChI key

XCGYUJZMCCFSRP-UHFFFAOYSA-N

Biochem/physiol Actions

Oxamniquine is an anthelmintic agent with schistosomicidal activity against Schistosoma mansoni.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anastasia Rugel et al.
ACS medicinal chemistry letters, 9(10), 967-973 (2018-10-23)
Schistosomiasis is a major human parasitic disease afflicting more than 250 million people, historically treated with chemotherapies praziquantel or oxamniquine. Since oxamniquine is species-specific, killing Schistosoma mansoni but not other schistosome species (S. haematobium or S. japonicum) and evidence for
Lidiany da Paixão Siqueira et al.
Acta tropica, 176, 179-187 (2017-08-15)
Neglected tropical diseases (NTDs) affect millions of people in different geographic regions, especially the poorest and most vulnerable. Currently NTDs are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. One of the most
Gordana Panic et al.
Antimicrobial agents and chemotherapy, 61(12) (2017-10-04)
To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to

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