PZ0129

CP-380736

≥98% (HPLC)

• Synonym(s): 6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one, 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone, PF-00520893
• Empirical Formula (Hill Notation): C₁₄H₁₈N₂O₅
• CAS Number: 179688-29-0
• Molecular Weight: 294.30
• MDL number: MFCD02678087
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823716
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to light tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: room temp
• SMILES string: COCCOc1cc2N=CNC(=O)c2cc1OCCOC
• InChI: 1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
• InChI key: PMQWTUWLIGJTQD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable