O5761
Osteocalcin fragment 1-49 Human
≥94% (HPLC), solid
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About This Item
Empirical Formula (Hill Notation):
C269H381N67O82S2
CAS Number:
Molecular Weight:
5929.43
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Quality Level
Assay
≥94% (HPLC)
form
solid
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... BGLAP(632)
Amino Acid Sequence
Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]
General description
Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.
Calcium-binding protein found in dentin and possibly other mineralized tissues.
Application
Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.
Biochem/physiol Actions
Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Identification and characterization of glycation adducts on osteocalcin
Corinne J
Analytical Biochemistry (2017)
An overview of osteocalcin progress.
Li J
Journal of Bone and Mineral Metabolism, 34(4), 367-379 (2016)
Hua Shen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(4), 596-605 (2014-10-29)
It is well-established that muscle forces are necessary for bone development as well as proper bone modeling and remodeling. Recent work has also suggested that bone acts as an endocrine organ that can influence the development of other organs. Connexin43
Osteocalcin Mediates Biomineralization during Osteogenic Maturation in Human Mesenchymal Stromal Cells
Yu-Tzu Tsao
International Journal of Molecular Sciences, 18(1), 159-159 (2017)
Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.
Martinez-Diaz-Guerra G
Hormone and Metabolic Research, 48(5), 325-330 (2016)
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