G6416

GW5074

powder

• Synonym(s): 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
• Empirical Formula (Hill Notation): C₁₅H₈Br₂INO₂
• CAS Number: 220904-83-6
• Molecular Weight: 520.94
• MDL number: MFCD03453076
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278455
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• storage condition: protect from light
• color: yellow to orange-brown
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: room temp
• SMILES string: Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
• InChI: 1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• InChI key: LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Gene Information: human ... RAF1(5894)

Description

Application

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

Other Notes

light sensitive

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves