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Key Documents

A9106

Sigma-Aldrich

ADP-ribosylcyclase

1000-3000 units/mg protein

Synonym(s):

Adenosine diphosphoribose cyclase from Aplysia californica

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About This Item

CAS Number:
135622-82-1
MDL number:
MFCD00212894
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

(Aplysia californica)

Quality Level

200

Assay

≥80 μ protein/vial (BCA)

form

lyophilized powder

specific activity

1000-3000 units/mg protein

composition

Protein, ≤10%

packaging

vial of ≥80 μg protein

storage condition

dry at room temperature

concentration

≤10% (BCA method)

suitability

suitable for enzyme test

application(s)

genomic analysis

storage temp.

−20°C

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Application

ADP-ribosylcyclase is a Ca2+ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

Biochem/physiol Actions

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

Unit Definition

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD+ in 5 minutes at pH 7.0 and 25°C.

Physical form

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H334

Precautionary Statements

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Heather S Loring et al.
Biochemistry, 59(8), 933-942 (2020-02-13)
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents degeneration, thereby demonstrating that SARM1
Lynn C Hull et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1042-1050 (2010-06-17)
Our previous studies have demonstrated that an increase in intracellular levels of Ca(2+) in neurons is an important component of both the antinociception produced by morphine and morphine's tolerance. The present study tested the hypothesis that the Ca(2+) signaling second
H C Lee et al.
Cell regulation, 2(3), 203-209 (1991-03-01)
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate (IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme responsible for synthesizing cADPR is found not only in sea urchin
Nicholas D Peterson et al.
eLife, 11 (2022-02-01)
Intracellular signaling regulators can be concentrated into membrane-free, higher ordered protein assemblies to initiate protective responses during stress - a process known as phase transition. Here, we show that a phase transition of the Caenorhabditis elegans Toll/interleukin-1 receptor domain protein
Xiaojian Shao et al.
Nature protocols, 15(9), 2813-2836 (2020-08-05)
Several noncanonical initial nucleotides (NCINs) have been found to cap RNAs and possibly regulate RNA stability, transcription and translation. NAD+ is one of the NCINs that has recently been discovered to cap RNAs in a wide range of species. Identification
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