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A8598

Sigma-Aldrich

Ancitabine hydrochloride

Synonym(s):

2,2′-Anhydro-(1-β-D-arabinofuranosyl)cytosine hydrochloride, Cyclo-C, Cyclocytidine

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About This Item

Empirical Formula (Hill Notation):
C9H11N3O4 · HCl
CAS Number:
10212-25-6
Molecular Weight:
261.66
EC Number:
233-515-6
MDL number:
MFCD00012636
UNSPSC Code:
12352200
PubChem Substance ID:
24278241
NACRES:
NA.77

form

powder

Quality Level

200

SMILES string

Cl[H].OC[C@H]1[C@H](O)O[C@@H]2[C@H]1OC3=NC(=N)C=C[N@@H]23

InChI

1S/C9H11N3O4.ClH/c10-5-1-2-12-8-7(16-9(12)11-5)6(14)4(3-13)15-8;/h1-2,4,6-8,10,13-14H,3H2;1H/t4-,6-,7+,8-;/m1./s1

InChI key

KZOWNALBTMILAP-JBMRGDGGSA-N

Application

Ancitabine hydrochloride is an antineoplastic agent for the treatment of lymphatic leukemia and sinus acceleration.

Biochem/physiol Actions

Antineoplastic

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tyramine-like effect of cyclocytidine (2,2'-anhydro-1-β-arabinofuranosylcytosine hydrochloride), an antineoplastic agent
Oguro, K., Hashimoto, K.
The Journal of Experimental Medicine, 124, 83-90 (1978)
M Hewish et al.
British journal of cancer, 108(4), 983-992 (2013-01-31)
DNA mismatch repair deficiency is present in a significant proportion of a number of solid tumours and is associated with distinct clinical behaviour. To identify the therapeutic agents that might show selectivity for mismatch repair-deficient tumour cells, we screened a

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