A2202
ω-Agatoxin TK
~98% (HPLC), powder
Synonym(s):
ω-Aga-TK
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About This Item
Empirical Formula (Hill Notation):
C215H337N65O70S10
CAS Number:
Molecular Weight:
5273.02
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
Assay
~98% (HPLC)
Quality Level
form
powder
solubility
H2O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)
storage temp.
−20°C
Gene Information
human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)
Amino Acid Sequence
Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala
Biochem/physiol Actions
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Y Q Lin et al.
Journal of the autonomic nervous system, 73(1), 26-37 (1998-11-10)
The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in the terminal boutons, (delta[Ca2+]b) following short (1 or 5 impulses) and
Q Q Sun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(18), 6839-6849 (1997-09-15)
The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ currents. In approximately 80% of the acutely
T Teramoto et al.
Biochemical and biophysical research communications, 196(1), 134-140 (1993-10-15)
In the course of purification of omega-Aga-IVA, a specific P-type calcium channel blocker, from the venom of Agelenopsis aperta we discovered a novel peptide. This peptide, named omega-agatoxin Tsukuba (omega-Aga-TK), also blocked P-type channels and was twelve times more abundant
D Dobrev et al.
Neuropharmacology, 37(8), 973-982 (1998-12-02)
The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of [3H]DA evoked by veratridine (25 microM) decreased by 50.6+/-2.9% (n=8) in the absence
T Teramoto et al.
Neuroreport, 6(12), 1684-1688 (1995-08-21)
We characterized the electrophysiological properties of calcium channels in cultured rat hippocampal neurones using omega-agatoxin-TK (omega-Aga-TK) and compared them with those of the P-type channel and the BI (alpha 1A) channel which resembles the Q-type channel. Two types of omega-Aga-TK-sensitive
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