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78544

Sigma-Aldrich

Glucose tetrasaccharide

≥99.0% (TLC)

Synonym(s):

Glcα1-6Glcα1-4Glcα1-4Glc

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About This Item

Empirical Formula (Hill Notation):
C24H42O21
CAS Number:
35175-16-7
Molecular Weight:
666.58
MDL number:
MFCD09840666
UNSPSC Code:
12352201
PubChem Substance ID:
329768157
NACRES:
NA.28

Quality Level

100

Assay

≥99.0% (TLC)

form

powder

color

white

suitability

corresponds for LC-MS

storage temp.

room temp

SMILES string

OC[C@H]1O[C@H](OC[C@H]2O[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)C(O)O[C@@H]4CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C24H42O21/c25-1-5-9(28)11(30)16(35)22(41-5)39-4-8-10(29)12(31)17(36)23(43-8)45-20-7(3-27)42-24(18(37)14(20)33)44-19-6(2-26)40-21(38)15(34)13(19)32/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10-,11+,12+,13-,14-,15-,16-,17-,18-,19-,20-,21?,22+,23-,24-/m1/s1

InChI key

FPBCRLIOSBQLHS-QVTSYAGHSA-N

Application

Glucose tetrasaccharide (Glc4) is used as a reference in analysis of urinary glucose tetrasacchaide, a biomarker for Pompe disease and other glycogen storage diseases.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Chihiro Yonee et al.
Brain & development, 34(10), 834-839 (2012-04-24)
Pompe disease is an autosomal recessive disorder caused by deficiency of the lysosomal enzyme, acid alpha-glucosidase (GAA). To the best of our knowledge, no studies have reported the results of systematic and sequential CT analyses before and during ERT. In
Unique oligosaccharide (apparently glucotetrasaccharide) in urine of patients with glycogen storage diseases.
K Oberholzer et al.
Clinical chemistry, 36(7), 1381-1381 (1990-07-01)
D A Zopf et al.
Journal of immunological methods, 48(1), 109-119 (1982-01-01)
A radioimmunoassay is described that allows rapid determination of a urinary oligosaccharide -- Glc alpha 1-6Glc alpha 1-4Glc alpha 1-4Glc [(Glc)4] -- at concentrations greater than 2 pmol/microliter. Antibodies produced in rabbits immunized with the phenethylamine derivative of (Glc)4 coupled
A Lundblad et al.
Journal of immunological methods, 68(1-2), 227-234 (1984-03-30)
Binding of a human urinary tetrasaccharide (Glc alpha 1-6Glc alpha 1-4Glc alpha 1-4Glc) by a mouse monoclonal antibody, 61.1, shows an unusually large dependence upon temperature. Association constants determined by equilibrium dialysis double for each 8 degrees C downward shift
Sarah P Young et al.
Analytical biochemistry, 316(2), 175-180 (2003-04-25)
Patients with glycogen storage disease type II (GSD II) typically excrete increased amounts of a glycogen-derived glucose tetrasaccharide, Glcalpha1-6Glcalpha1-4Glcalpha1-4Glc (Glc(4)), in the urine. With the advent of a new enzyme replacement therapy for GSD II, there is a need for
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