30290
Cytidine 5′-diphosphocholine sodium salt hydrate
≥99.0% (HPLC)
Synonym(s):
CDP-choline-Na
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C14H25N4NaO11P2 · xH2O
CAS Number:
Molecular Weight:
510.31 (anhydrous basis)
Beilstein:
4110040
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Recommended Products
biological source
synthetic
Quality Level
Assay
≥99.0% (HPLC)
form
powder
impurities
≤8% water
storage temp.
2-8°C
SMILES string
[Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O
InChI
1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1
InChI key
YWAFNFGRBBBSPD-MBWJOHGMSA-M
Application
Cytidine 5′-diphosphocholine (CDP-choline) is generated by choline-phosphate cytidylyltransferase EC 2.7.7.15 in support of the synthesis of phosphatidylcholine. CDP-choline is being used in studies of its affects on neurorecovery.
Cytidine 5′-diphosphocholine sodium salt hydrate has been used as a component of the mixture during the ribonucleotide reductase (RNR) assay in mouse primary pancreatic acinar cells.
Biochem/physiol Actions
Cytidine 5′-diphosphocholine (CDP-choline) is an endogenous compound that plays an important role in the synthesis of phospholipids in the cell membrane. It acts as a choline donor for the biosynthesis of acetylcholine and phosphatidylcholine, a neuronal membrane phospholipid. CDP-choline enhances brain metabolism and influences the levels of various neurotransmitters including dopamine, epinephrine, and acetylcholine. It has been studied as a neuroprotectant after cerebral ischemia. CDP-choline is observed to exhibit therapeutic effects against cognitive impairment arising from multiple causes, cerebral vascular diseases, after-head trauma, and Alzheimer′s disease.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Patricia M Arenth et al.
PM & R : the journal of injury, function, and rehabilitation, 3(6 Suppl 1), S123-S131 (2011-07-08)
Cytidine 5'-diphosphocholine (CDP-choline or citicoline) is a highly bioavailable compound with potential benefits for aiding neural repair and increasing acetylcholine levels in the central and peripheral nervous system. As a result, many researchers have investigated the use of CDP-choline for
Erhan Aslan et al.
Neurological research, 33(7), 766-773 (2011-07-16)
Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the
Deniz Bagdas et al.
Behavioural pharmacology, 22(5-6), 589-598 (2011-08-13)
This study was designed to test the effects of intracerebroventricularly (i.c.v.) administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 µmol) produced a dose and
Tomás Sobrino et al.
Neurological research, 33(6), 572-577 (2011-06-29)
The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after
Lorissa J Niebergall et al.
Biochimica et biophysica acta, 1811(12), 1177-1185 (2011-07-13)
Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service