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22140

Sigma-Aldrich

Celite® 545

filter aid, treated with sodium carbonate, flux calcined

Synonym(s):

Diatomaceous earth, flux-calcined

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About This Item

CAS Number:
68855-54-9
EC Number:
272-489-0
MDL number:
MFCD00132803
UNSPSC Code:
11101527
PubChem Substance ID:
329752266
NACRES:
SB.54

Quality Level

200

form

powder

quality

flux calcined
treated with sodium carbonate

composition

Al2O3, 1.0%
CaO, 6.73%
Fe2O3, 0.46%
Na2O + K2O, 1.88%
SiO2, 89.0%

median particle size

≤125.30 μm (71% (acc. to Cilas))

pH

>8.5 (25 °C, 10% in aq. suspension)

SMILES string

O=[Si]=O

InChI

1S/O2Si/c1-3-2

InChI key

VYPSYNLAJGMNEJ-UHFFFAOYSA-N

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General description

Diatomaceous earth is made up of natural amorphous silica formed from the fossilized skeletons of diatoms. It is extracted, crushed, dried and calcined with flux material. DE is widely used as filler in construction materials, paints and as an anti-caking agent for agricultural chemicals. It has high water and oil absorption ability.

Application

Diatomaceous earth may be used as an adsorbent for column chromatography.

Caution

Not Intended for cGMP Parenteral Pharmaceutical Manufacturing

Legal Information

Celite is a registered trademark of Imerys Minerals California, Inc.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H372

Precautionary Statements

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1 Inhalation

Target Organs

Lungs

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Immobilization of lipases on clay, Celite 545, diethylaminoethyl-, and carboxymethyl-Sephadex and their interesterification activity.
Ansari SA and Husain Q.
Biotechnol. Tech., 12(5), 381-384 (1998)
Lactose hydrolysis from milk/whey in batch and continuous processes by concanavalin A-Celite 545 immobilized Aspergillus oryzae ? galactosidase.
Ansari SA and Husain Q.
Food and Bioproducts Processing, 90(2), 351-359 (2012)
Direct immobilization of polyphenol oxidases on Celite 545 from ammonium sulphate fractionated proteins of potato (Solanum tuberosum).
Khan AA, et al.
Journal of Molecular Catalysis. B, Enzymatic, 40(1), 58-63 (2006)
Violeta Chitu et al.
Cell reports, 30(9), 3004-3019 (2020-03-05)
CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r+/- mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues most behavioral deficits
Yueru Li et al.
The American journal of pathology, 190(9), 1971-1981 (2020-06-27)
Leakage of retinal blood vessels, which is an essential element of diabetic retinopathy, is driven by chronic elevation of vascular endothelial growth factor (VEGF). VEGF quickly relaxes the endothelial cell barrier by triggering signaling events that post-translationally modify pre-existing components
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