T8656

Thiourea

ACS reagent, ≥99.0%

• Synonym(s): Sulfourea, Thiocarbamide
• Linear Formula: NH₂CSNH₂
• CAS Number: 62-56-6
• Molecular Weight: 76.12
• Beilstein: 605327
• EC Number: 200-543-5
• MDL number: MFCD00008067
• UNSPSC Code: 12352100
• PubChem Substance ID: 24900549
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• Assay: ≥99.0%
• ign. residue: ≤0.1% (as SO₄)
• loss: ≤0.5% loss on drying, 105°C, 2h
• mp: 170-176 °C (lit.); 174-177 °C
• solubility: H₂O: passes test
• SMILES string: NC(N)=S
• InChI: 1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
• InChI key: UMGDCJDMYOKAJW-UHFFFAOYSA-N
• Gene Information: mouse ... Ephx2(13850)

Description

General description

Thiourea is an analogue of urea containing sulphur.

Application

Thiourea has been used:

• as a component of lysis buffer for liver tissue homogenization
• in 2-D sample buffer for two-dimensional in-gel protein tyrosine phosphatases (PTP) assay
• in rehydration buffer for protein extraction

Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins

Biochem/physiol Actions

Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H351,H361fd,H411
• Precautionary Statements: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves