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43963

Millipore

Moxalactam Supplement

suitable for microbiology

Synonym(s):

Listeria MOX Supplement

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About This Item

Empirical Formula (Hill Notation):
C20H20N6O9S
CAS Number:
64952-97-2
Molecular Weight:
520.47
EC Number:
265-287-9
MDL number:
MFCD00865991
UNSPSC Code:
41171614
PubChem Substance ID:
329756436
NACRES:
NA.85

sterility

sterile

Quality Level

100

form

powder

shelf life

limited shelf life, expiry date on the label

application(s)

environmental
food and beverages
microbiology

storage temp.

2-8°C

suitability

Listeria spp.

SMILES string

CO[C@]2(NC(=O)C(C(O)=O)c1ccc(O)cc1)[C@H]3OCC(CSc4nnnn4C)=C(N3C2=O)C(O)=O

InChI

1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1

InChI key

JWCSIUVGFCSJCK-CAVRMKNVSA-N

General description

An antibiotic supplement recommended for selective isolation and cultivation of Listeria monocytogenes.

Application

for selective isolation and cultivation of Listeria monocytogenes

Components

(per vial, sufficient for 1000 ml medium)
Moxalactam 20.0 mg

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL5467
BCCM4077
BCCJ8290
BCCG5972
BCCC3601

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Xiaojun Wang et al.
Proteins, 47(1), 86-96 (2002-03-01)
The class A beta-lactamase TEM-1 is a key bacterial resistance enzyme against beta-lactam antibiotics, but little is known about the energetic bases for complementarity between TEM-1 and its inhibitors. Most inhibitors form a covalent adduct with the catalytic Ser70, making
Lionel Vercheval et al.
The Biochemical journal, 432(3), 495-504 (2010-11-27)
The activity of class D β-lactamases is dependent on Lys70 carboxylation in the active site. Structural, kinetic and affinity studies show that this post-translational modification can be affected by the presence of a poor substrate such as moxalactam but also
Julian R Garneau et al.
Journal of clinical microbiology, 57(5) (2019-02-15)
The epidemiology of Clostridioides difficile infection (CDI) has drastically changed since the emergence of the epidemic strain BI/NAP1/027, also known as ribotype 027 (R027). However, the relationship between the infecting C. difficile strain and clinical outcomes is still debated. We
James Spencer et al.
Journal of the American Chemical Society, 127(41), 14439-14444 (2005-10-13)
Metallo-beta-lactamases are zinc-dependent enzymes responsible for resistance to beta-lactam antibiotics in a variety of host bacteria, usually Gram-negative species that act as opportunist pathogens. They hydrolyze all classes of beta-lactam antibiotics, including carbapenems, and escape the action of available beta-lactamase
Markus Fridén et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 30(1), 150-161 (2009-09-17)
A major challenge associated with the determination of the unbound brain-to-plasma concentration ratio of a drug (K(p,uu,brain)), is the error associated with correction for the drug in various vascular spaces of the brain, i.e., in residual blood. The apparent brain
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