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Key Documents

AB10522

Sigma-Aldrich

Anti-Neuropilin-2 Antibody

serum, from rabbit

Synonym(s):

Vascular endothelial cell growth factor 165 receptor 2, neuropilin 2, receptor for VEGF165 and semaphorins class 3, vascular endothelial growth factor-165 receptor 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NP_110496.1

UniProt accession no.

O35276

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... NRP2(8828)

General description

There are two forms of Neuropilin: Neuropilin-1 and Neuropilin-2. These are non–tyrosine kinase receptors that bind to VEGF and semaphorins (SEMA3A, SEMA3B, and SEMA3F) and play an important role in the critical functioning of the nervous system. Neuropilin-2 is expressed in tumor cells, and mature and developing endothelial cells and vascular smooth muscle cells. This expression has been associated with tumor angiogenesis and progression.

Specificity

This antibody recognizes Neuropilin-2.

Immunogen

His-tagged partial recombinant rat Neuropilin-2 protein.

Application

Detect Neuropilin-2 using this Anti-Neuropilin-2 Antibody validated for use in WB, IH, IP & IF.

Quality

Evaluated by Western Blot in mouse P1 brain tissue lysate.

Western Blot Analysis: 1:1000 dilution of this antibody detected Neuropilin-2 on 10 µg of mouse P1 brain tissue lysate.

Target description

130 kDa

Linkage

Replaces: AB9160

Physical form

Unpurified Rabbit Serum containing 0.05% Sodium Azide.

Analysis Note

Control
Mouse P1 brain tissue lysate

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Saravana K Ramasamy et al.
Nature, 507(7492), 376-380 (2014-03-22)
Blood vessel growth in the skeletal system and osteogenesis seem to be coupled, suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells. Understanding the nature of the mechanisms linking angiogenesis and bone formation should be of great relevance
Ryosuke Tsuchimochi et al.
Stem cell reports, 18(4), 899-914 (2023-03-25)
Cell replacement therapy is expected as a new and more radical treatment against brain damage. We previously reported that transplanted human cerebral organoids extend their axons along the corticospinal tract in rodent brains. The axons reached the spinal cord but

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