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521000-M

Millipore

Phenylarsine Oxide

A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀ = 18 µM).

Synonym(s):

Phenylarsine Oxide, PAO, Oxophenylarsine, PTP Inhibitor IX, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C6H5AsO
CAS Number:
Molecular Weight:
168.02
MDL number:
UNSPSC Code:
12352119

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Quality Level

Assay

≥96% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

chloroform: 100 mg/mL
DMSO: 50 mg/mL

storage temp.

10-30°C

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

General description

A membrane-permeable phosphotyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates P56lck protein tyrosine kinase. Blocks TNFα-dependent activation of the NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases, as well as endogenous chicken caspases that are active in extracts of preapoptotic chicken DU249 cells (S/M extracts). At 100 µM, it also blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.
A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).

Biochem/physiol Actions

Primary Target
Protein tyrosine phosphatase
Target IC50: 18 µM against protein tyrosine phosphatase

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Takahashi, A., et al. 1997. Exp. Cell Res.231, 123.
Carey, J.O., et al. 1995. Diabetes44, 1995.
Le Cabec, V., and Maridonneau-Parini, I. 1995. J. Biol. Chem.270, 2067.
Oetken, C., et al. 1995. Mol. Immunol.31, 1295.
Singh, S., and Aggarwal, B.B. 1995. J. Biol. Chem.270, 10631.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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