biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
monoclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... IKBKG(8517)
General description
IKKγ/IKK3 is also known as NEMO, FIP-3 and IKKAP-1
Specificity
IKKγ/IKK3
Immunogen
His-tagged, full-length human IKKgamma/IKK3
Application
Anti-IKKγ Antibody is an antibody against IKKγ for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Immunological Signaling
Quality
routinely evaluated by immunoblot on RIPA lysates from Jurkat cells
Target description
48kDa
Physical form
Format: Purified
PBS, pH 7.4, containing 0.05% sodium azide
Protein G Chromatography
Storage and Stability
2 years at -20°C
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Oncoprotein Suppression of Tumor Necrosis Factor-induced NF{kappa}B Activation Is Independent of Raf-controlled Pathways
Hanson, J. L., et al
The Journal of Biological Chemistry, 278, 34910-34917 (2003)
Sandeep Rana et al.
Chemical biology & drug design, 96(2), 773-784 (2020-04-03)
The release of an active drug from the prodrug generates a pro-fragment that typically has no biological activity and could result in adverse effects. By combining two drugs, wherein each drug acts as a pro-fragment of the other drug will
Masaaki Morikawa et al.
Microbiology (Reading, England), 152(Pt 9), 2801-2807 (2006-09-02)
The extracellular matrix produced by Bacillus subtilis B-1, an environmental strain that forms robust floating biofilms, was purified, and determined to be composed predominantly of gamma-polyglutamate (gamma-PGA), with a molecular mass of over 1,000 kDa. Both biofilm formation and gamma-PGA
Maarten F de Jong et al.
Nature microbiology, 1(7), 16084-16084 (2016-08-31)
The linear ubiquitin chain assembly complex (LUBAC) is a multimeric E3 ligase that catalyses M1 or linear ubiquitination of activated immune receptor signalling complexes (RSCs). Mutations that disrupt linear ubiquitin assembly lead to complex disease pathologies including immunodeficiency and autoinflammation
Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury.
Dheeraj Soni et al.
Cell death discovery, 4, 60-60 (2018-05-26)
Vascular endothelial cadherin (VE-cad) expression at endothelial adherens junctions (AJs) regulates vascular homeostasis. Here we show that endothelial A20 is required for VE-cad expression at AJs to maintain and repair the injured endothelial barrier. In endothelial cell (EC)-restricted Tnfaip3 (A20)
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