N-008
S(−)-Nicotine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Synonym(s):
(−)-Nicotine solution
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About This Item
Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
Molecular Weight:
162.23
Beilstein:
5733110
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
SMILES string
CN1CCC[C@H]1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
InChI key
SNICXCGAKADSCV-JTQLQIEISA-N
Gene Information
human ... CHRNA4(1137) , CHRNB2(1141)
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General description
A Certified Spiking Solution® applicable for use in LC/MS or GC/MS applications such as nicotine testing, forensic analysis or clinical and diagnostic testing. Nicotine is a highly additive tobacco alkaloid associated with numerous health risks such as heart health, mental health and cancer.
Application
- Chiral nicotine for neuroreceptor research: S(−)-Nicotine solution is extensively used in neuroreceptor studies, particularly targeting cholinergic receptors. This enantiopure nicotine variant helps in understanding the binding affinity and activity differences between nicotine isomers, contributing to more targeted neuropharmacological interventions (Lu and Gao, 2024).
- Pharmacological experiments in addiction research: The optically active form of S(−)-Nicotine is critical for addiction research, where it is used to investigate the pharmacodynamics and addictive properties of nicotine. Studies using this compound help in developing therapeutic strategies for smoking cessation and understanding the biochemical pathways involved in nicotine addiction (Yang et al., 2024).
- Enantiomer specificity in biochemical studies: High purity S(−)-Nicotine is crucial for assays that require precise control over biochemical properties. Its application in cholinergic receptor assays helps to elucidate the specific interactions and effects of the S(−) enantiomer compared to its R(+) counterpart, thereby enhancing the accuracy of pharmacological models (Mancuso et al., 2024).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Product No.
Description
Pricing
WGK
""
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
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