D-048

N-Desmethylclozapine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₇H₁₇ClN₄
• CAS Number: 6104-71-8
• Molecular Weight: 312.80
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
• InChI: 1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
• InChI key: JNNOSTQEZICQQP-UHFFFAOYSA-N

Description

General description

N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril^® and FrazaClo in the US. This Certified Snap-N-Spike^® Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.

Application

• Pharmacokinetic analysis of clozapine and N-Desmethylclozapine: A study conducted by Mach et al. (2024) analyzed clinical and pharmacological factors that influence serum levels of clozapine and its metabolite N-Desmethylclozapine, offering insights into dosing strategies and metabolic pathways relevant to schizophrenia treatment (Mach et al., 2024).



• Chromatographic profiling for clozapine and its metabolites: Hrichi et al. (2024) reviewed chromatographic methods for analyzing antipsychotic drugs, including clozapine and N-Desmethylclozapine, to improve the accuracy of pharmacokinetic studies and enhance drug monitoring capabilities (Hrichi et al., 2024).



• Influence of lifestyle factors on clozapine metabolism: Research by Flanagan et al. (2024) explored the impact of coffee and chocolate ingestion on the plasma concentrations of clozapine and its metabolite N-Desmethylclozapine, providing data crucial for understanding how dietary habits affect antipsychotic drug levels (Flanagan et al., 2024).

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Clozaril is a registered trademark of Sandoz, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup