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D-019

Supelco

Dihydrocodeine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H23NO3·HCl
CAS Number:
36418-29-8
Molecular Weight:
337.84
EC Number:
200-659-6
MDL number:
MFCD00190607
UNSPSC Code:
41116107
PubChem Substance ID:
329798591
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

Cl.COc1ccc2C[C@@H]3[C@@H]4CC[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI

1S/C18H23NO3.ClH/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3;1H/t11-,12+,13-,17-,18-;/m0./s1

InChI key

VMZXMTVGOAQUEN-FFHNEAJVSA-N

General description

A Certified Snap-N-Spike® Solution suited for use as starting material in calibrators and controls for a variety of LC/MS or GC/MS applications from urine drug testing and pain prescription monitoring to forensic analysis and pharmaceutical research. Dihydrocodeine is an opioid analgesic developed for treatment of moderate to severe pain and as an antitussive.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-021

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wojciech Leppert
Current drug metabolism, 11(6), 494-506 (2010-06-15)
Dihydrocodeine (DHC) is a semi-synthetic analogue of codeine which was formed by the hydrogenation of the double tie in the main chain of the codeine molecule. DHC is used as an analgesic, antitussive and antidiarrhoeal agent; it is also used
W Leppert et al.
International journal of clinical practice, 64(12), 1681-1687 (2010-10-16)
Tramadol and dihydrocodeine (DHC) are analgesics of step 2 WHO analgesic ladder (opioids for mild to moderate pain, weak opioids) frequently used in the treatment of cancer pain of moderate intensity. The aim of the study was to assess the
Giuliano Zamparutti et al.
British journal of clinical pharmacology, 72(2), 330-337 (2011-01-18)
Dihydrocodeine (DHC) is an opioid analgesic sometimes prescribed as an alternative to other medications (e.g. methadone and buprenorphine) for opioid misuse. Its effectiveness is, however, still controversial. DHC prescription rates seem to be related to levels of DHC fatalities, possibly
[Q & A. A patient brought in a comatose state, displaying acute hepatic disorder and an area of high absorption in the stomach in CT images].
Motohiko Tanaka et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 108(4), 665-666 (2011-06-24)
Yvonne H Tak et al.
Journal of chromatography. A, 1267, 138-143 (2012-09-11)
In this study, in-line frit-free solid-phase extraction (SPE) has been studied for the preconcentration of analytes prior to analysis by capillary electrophoresis-mass spectrometry (CE-MS). The mixed-mode sorbent Oasis HLB was selected for the trapping of compounds of different polarity. Using
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