850546P
Avanti
MSDH
Avanti Research™ - A Croda Brand 850546P, powder
Synonym(s):
(S)-O-methyl-serine dodecylamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H35ClN2O2
CAS Number:
Molecular Weight:
322.91
UNSPSC Code:
12161902
NACRES:
NA.25
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Assay
>99% (TLC)
form
powder
mol wt
322.91 g/mol
packaging
pkg of 1 × 25 mg (850546P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850546P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]
General description
O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.
Application
MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.
Biochem/physiol Actions
O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.
Packaging
5 mL Amber Glass Screw Cap Vial (850546P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
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