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W431300

Sigma-Aldrich

Hesperetin

≥95%

Synonym(s):

3′,5,7-Trihydroxy-4′-methoxyflavanone, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone

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About This Item

Empirical Formula (Hill Notation):
C16H14O6
CAS Number:
69097-99-0
Molecular Weight:
302.28
FEMA Number:
4313
MDL number:
MFCD00016956
UNSPSC Code:
12164502
PubChem Substance ID:
329830698
Flavis number:
16.097
NACRES:
NA.21

biological source

synthetic

Quality Level

400

Assay

≥95%

form

powder (with a light tan cast)

mp

227-232 °C

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

odorless

SMILES string

COc1ccc(cc1O)C2CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3

InChI key

AIONOLUJZLIMTK-UHFFFAOYSA-N

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Disclaimer

For R&D or non-EU Food use. Not for retail sale.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xuan Zeng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1136, 121846-121846 (2019-12-11)
Naringin has been documented to possess multiple pharmacological activities. Reported pharmacokinetic studies revealed that oral bioavailability of naringin was low, in contrast to its significant pharmacological effects. The in vivo distribution of naringin and derived metabolites might partly explain this
Ramesh Elango et al.
Journal of Asian natural products research, 20(6), 559-569 (2017-05-26)
We studied the chemoprevention property of hesperetin on H522 cells using MTT, an apoptosis assay, an analysis of cell cycle progression, and the mitochondrial membrane potential, and apoptotic marker gene expression was determined using quantitative PCR. Hesperetin enhanced apoptotic cell
Elena Valeria Fuior et al.
Pharmaceutics, 11(8) (2019-08-07)
Citrus flavonoids have well-documented protective effects on cardiovascular system, but the poor water solubility and reduced bioavailability restrict their therapeutic use. We aimed to overcome these limitations and encapsulated naringenin and hesperetin into lipid nanoemulsions (LNs), targeted to vascular cell
Chuye Ji et al.
International journal of biological macromolecules, 168, 775-783 (2020-11-24)
The interaction between biomacromolecules and ligands has attracted great interest because of their biological properties. Calf thymus DNA (ctDNA) can interact with bioactive compounds to form complexes. Here, ctDNA-ligand complexes were studied using fluorescence, absorption, and infrared spectroscopy, circular dichroism
Weixin Wang et al.
Journal of agricultural and food chemistry, 63(43), 9488-9495 (2015-10-13)
The objective of this study was to investigate the ability of resveratrol and hesperetin to scavenge acrolein at pH 7.4 and 37 °C. About 6.4 or 5.2% of acrolein remained after reaction with resveratrol or hesperetin for 12 h at
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