Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

913235

Sigma-Aldrich

Acetylated branched polyethylenimine solution

20% acetylation, suitable for biomedical research

Synonym(s):

Acetylated PEI, Acetylated-PEI25K, Capped PEI

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
(C29H63N11O3)mC3H8N2O
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Acetylated branched polyethylenimine solution 20% solution, 20% acetylation, suitable for biomedical research

Quality Level

100

form

liquid

concentration

20 wt. % in water

color

pale yellow to yellow

storage temp.

2-8°C

Application

High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo. N-Acetylation of PEI could lower its toxicity. At low degree of substitution (below 25%) resulted in moderate improvement of transfection activity.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCM3641

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Nathan P Gabrielson et al.
Biomacromolecules, 7(8), 2427-2435 (2006-08-15)
We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine (PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride. In the present work, we investigated the effects of further increasing the degree of
M Laird Forrest et al.
Pharmaceutical research, 21(2), 365-371 (2004-03-23)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating
Arkadi Zintchenko et al.
Bioconjugate chemistry, 19(7), 1448-1455 (2008-06-17)
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of

Articles

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service