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Key Documents

640573

Sigma-Aldrich

Cyclopropanesulfonyl chloride

95%

Synonym(s):

Cyclopropylsulfonyl chloride

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About This Item

Empirical Formula (Hill Notation):
C3H5ClO2S
CAS Number:
Molecular Weight:
140.59
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

95%

refractive index

n20/D 1.4770 (lit.)

density

1.38 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

ClS(=O)(=O)C1CC1

InChI

1S/C3H5ClO2S/c4-7(5,6)3-1-2-3/h3H,1-2H2

InChI key

PFWWSGFPICCWGU-UHFFFAOYSA-N

Application

Cyclopropanesulfonyl chloride can be used in the synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic sulfonamide derivatives, which can serve as building blocks in the preparation of potent hepatitis C virus NS3 protease inhibitors.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

204.8 °F - closed cup

Flash Point(C)

96 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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"Concise asymmetric synthesis of a (1R, 2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl ester"
Lou Sha, et al.
Organic & Biomolecular Chemistry, 11(39), 6796-6805 (2013)

Articles

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

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