Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

184314

Sigma-Aldrich

Tetrahydrofuran-d8

≥99.5 atom % D

Synonym(s):

THF-d8, Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C4D8O
CAS Number:
1693-74-9
Molecular Weight:
80.16
Beilstein:
111854
MDL number:
MFCD00044238
UNSPSC Code:
12142201
PubChem Substance ID:
24851108
NACRES:
NA.21

isotopic purity

≥99.5 atom % D

Quality Level

200

Assay

≥99% (CP)

form

liquid

technique(s)

NMR: suitable

impurities

≤0.03% water
water

refractive index

n20/D 1.403 (lit.)

bp

65-66 °C (lit.)

mp

−106 °C (lit.)

density

0.985 g/mL at 25 °C (lit.)

mass shift

M+8

storage temp.

2-8°C

SMILES string

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChI key

WYURNTSHIVDZCO-SVYQBANQSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Tetrahydrofuran-d8 (THF-d8), a deuterated derivative of tetrahydrofuran, is a standard purity solvent suitable for routine NMR analyses (conducted at ambient temperatures where quality is less critical). It participates as a solvent in an intermolecular proton exchange reaction between methanol and acetic acid. Kinetics of this reaction has been studied by ′H NMR line shape analysis. Infrared spectral studies of THF and THF-d8 have been investigated in the range of 10 and 300cm-1.
Tetrahydrofuran-d8 may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.

Recommended products

Check out ChemisTwin®, our brand new online portal for identity confirmation and quantification of NMR spectra. Learn more or reach out to us for a free trial.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

1.4 °F - closed cup

Flash Point(C)

-17 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Far-Infrared Spectrum of Tetrahydrofuran: Spectroscopic Evidence for Pseudorotation.
Lafferty WJ, et al.
J. Chem. Phys. , 42(8), 2915-2919 (1965)
Dynamic NMR study of the interference between cyclic proton exchange, selfassociation and hindered rotation of diphenylformamidine in tetrahydrofuran.
Meschede L, et al.
Berichte der Bunsengesellschaft fur physikalische Chemie, 92(4), 469-485 (1988)
NMR lineshape theory of superimposed intermolecular spin exchange reactions and its action to the system acetic acid/methanol/tetrahydrofuran-d8.
Limbach HH.
Journal of Magnetic Resonance, 36(3), 287-300 (1979)
Alejandro G Lichtscheidl et al.
Dalton transactions (Cambridge, England : 2003), 44(36), 16156-16163 (2015-08-22)
The synthesis and full characterization, including Nuclear Magnetic Resonance (NMR) data ((1)H, (13)C{(1)H} and (119)Sn{(1)H}), for a series of Me3SnX (X = O-2,6-(t)Bu2C6H3 (), (Me3Sn)N(2,6-(i)Pr2C6H3) (), NH-2,4,6-(t)Bu3C6H2 (), N(SiMe3)2 (), NEt2, C5Me5 (), Cl, Br, I, and SnMe3) compounds in

Articles

NMR Deuterated Solvent Properties Reference Chart

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

NMR Deuterated Solvent Properties Reference Chart

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

NMR Deuterated Solvent Properties Reference Chart

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

NMR Deuterated Solvent Properties Reference Chart

Use this reference table to find the coupling values and chemical shifts of our NMR (deuterated) solvents. Melting and boiling points, molecular weight, density, and CAS number are also listed.

Related Content

Nuclear Magnetic Resonance (NMR)

NMR spectroscopy elucidates molecular structure and purity via nuclear spin states in a strong magnetic field.

Nuclear Magnetic Resonance (NMR)

NMR spectroscopy elucidates molecular structure and purity via nuclear spin states in a strong magnetic field.

Nuclear Magnetic Resonance (NMR)

NMR spectroscopy elucidates molecular structure and purity via nuclear spin states in a strong magnetic field.

Nuclear Magnetic Resonance (NMR)

NMR spectroscopy elucidates molecular structure and purity via nuclear spin states in a strong magnetic field.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service